Paul Gadue, Ph.D.

Paul Gadue, Ph.D.

Assistant Professor of Pathology

Department of Pathology and Laboratory Medicine

The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
CTRB, Rm. 5012
Philadelphia, PA 19104

(267)426-9607

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Biography

I joined the Children’s Hospital of Philadelphia (CHOP) and University of Pennsylvania faculty in 2008 as an Assistant Professor. I am a Stem Cell Biologist, and have been studying pluripotent stem cell differentiation for 10 years. I am a member of CHOP’s Center for Cellular and Molecular Therapeutics and UPenn’s Institute of Regenerative Medicine. Since arriving at CHOP, Deborah French and myself have established the Human Stem Cell Core. This facility provides services and training on the culture and differentiation of human pluripotent stem cells, including human embryonic stem (ES) cells and induced pluripotent stem (iPS) cells. Our facility also generates human iPS cells from patient samples and has introduced this technology to the CHOP and UPenn research communities. My research laboratory focuses on understanding the mechanisms that control the differentiation of pluripotent stem cells into functional derivative tissues with a focus on hematopoietic lineages, liver, and pancreas.

My postdoctoral training was with Dr. Gordon Keller at the Mt. Sinai School of Medicine in New York NY. My research defined the role of several singling pathways in the generation of hematopoietic and endodermal lineage cells from ES cells. I received my Ph.D. from the University of Pennsylvania in the field of Immunology, studying lymphocyte development.