Gerd Blobel, M.D., Ph.D.

Gerd Blobel, M.D., Ph.D.

Professor of Pediatrics

Department of Pediatrics

The Children's Hospital of Philadelphia
316H Abramson Research Center
3615 Civic Center Blvd.
Philadelphia, PA 19104


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Our lab focuses on the transcriptional control of hematopoiesis and its disorders. Specifically, we study how tissue-specific transcription factors govern the specification and maintenance of hematopoietic cell lineages. We also examine how transcription programs are epigenetically transmitted through mitosis to maintain lineage identity. Our work is leading us deeply into the analysis of chromatin structure, its modifications, and organization. For example, we investigate how regulatory elements are organized spatially using chromosome conformation capture technology. We are also interested in the control of transcription factors by posttranslational modifications. For our studies we combine molecular, genomic, biochemical, and microscopic approaches with studies in normal and gene targeted mice.