Monica Bessler, M.D., Ph.D.

Monica Bessler, M.D., Ph.D.

Professor of Pediatrics

Department of Pediatrics

The Children’s Hospital of Philadelphia and Perelman School of Medicine
University of Pennsylvania Health System
Abramson Research Center
3615 Civic Center Blvd., Room 302
Philadelphia, PA 19104

(267) 426-8782

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Our research aims to define the molecular mechanisms that cause bone marrow failure and the factors that determine the clinical outcome and response to treatment. Bone marrow failure (BMF) is the inability of the bone marrow to produce sufficient blood cells. BMF may be brought about by a number of causes; these may be genetic (inherited bone marrow failure syndromes, IBMFS) or acquired. BMF may affect all, or only individual blood cell lineages. Our aims are to develop more specific tests or biomarkers that distinguish and diagnose individual forms of BMF; to identify the pathways that lead to BMF; to characterize the pathways responsible for late complications, such as the development of myelodysplastic syndrome (MDS) and leukemia; and to investigate specific and more targeted treatments for patients with BMF, allowing personalized therapy for patients with problems in blood cell production.

Home Participating Investigators Monica Bessler, M.D., Ph.D.